Chronic alcohol intake induces liver injury and neuroinflammation in the hippocampus and prefrontal cortex, which impairs memory and cognition in correlation with inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP1), and interleukin-1β (IL-1β), suggesting a liver–brain axis contributing to cognitive decline [5,28]. The gene discussed is IL1B; the disease is Mental deterioration.