CBR1 and Parkinson disease: In PD, low CBR1 levels in the middle superior frontal gyrus were associated with general cognitive disfunction, impaired executive functions, and poor episodic memory, and in patients with severe visual-spatial dysfunction, CBR1 content decreased in the precuneus, motor cortex, middle cortex, additional motor cortex, lower orbitofrontal gyrus, and thalamus [75].