BRAF and neoplasm: Apart from some radiological (presence of macrocalcifications, circumscribed or nodular–diffuse aspect) and histological (ganglioma-like or piloid–HGG aspect, CD34 extravascular staining) differences, they also found that tumours with the co-occurrence of H3.3 K27M and BRAF or FGFR1 mutations tend to form their own cluster in unsupervised clustering methylation analysis, segregated from diffuse midline gliomas, H3K27-altered.