MYCN and central nervous system cancer: One postulated mechanism for MYCN enrichment relies on FBXW7 deletion (located in chromosome 4q31.3; 4q loss is found in 70% of H3G34-altered gliomas) [64,73], which is a component of the SCF-like ubiquitin ligase complex that targets MYC/MYCN for proteasomal degradation [2,74].