EZHIP and diffuse midline glioma: Diffuse midline glioma (DMG), H3K27-altered is an infiltrative midline glioma with the loss of H3 p.K28me3 and usually either an H3 c.83A>T p. K28M substitution in one of the histone H3 isoforms, an aberrant overexpression of EZHIP, or an EGFR mutation [4].