There is also the enrichment of some alterations according to histology amplifications (morphology is commented in 3.5 Pathological features): The glioblastoma multiform-like (GBM-like) histology showed enrichment in PDGFRA and CDK6 amplifications, while the PNET-like histology showed a higher incidence of CCND2 [64]. The gene discussed is CCND2; the disease is glioblastoma.