NOS2 and cancer: Compounds like 9–12 (Figure 9) mainly acted as anti-inflammatory agents able to modulate the NF-kB pathway in inflamed cellular models, such as in PAM212 keratinocytes and different cancer cells (9, 10) [68,69], BV2 cells (11) [70], and RAW 264.7 macrophages (12) [71], resulting in a reduction in iNOS expression.