HMOX1 and Sepsis: Studies have shown that naringin, the glycoside form of naringenin, reduces the production of inflammatory cytokines in sepsis models via various signaling pathways, such as Kelch-like ECH-associated protein 1 (KEAP1)/Nrf-2/heme oxygenase-1 (HO-1) [188], Ras homolog family member A-associated protein kinase/NF-κB/Myosin light-chain kinase (MLCK)/myosin light chain (MLC) (RhoA/ROCK/NF-κB/MLCK/MLC [187], PI3K/AKT [188], and MAPK/AMPK [382].