GSDMD and Sepsis: One formulation of a curcumin and arginine–glycine–aspartic acid nanotherapeutic was shown to target and inhibit macrophages via a decreased production of caspase-1, caspase-3, NOD-like receptor 3 (NLRP3), IL-1β, and Gasdermin D (GSDMD), which are responsible for mediating the pyroptosis seen in cytokine release syndrome and specific organ injury according to in vitro sepsis [140].