Furthermore, in vivo and in vitro studies have also shown curcumin to increase mitochondrial synthesis and prevent destruction via SIRT1-dynamin-related protein 1 (DRP1)/peroxisome proliferator-activated receptor-γ coactivator 1-α (PGC1α) pathway, thus exhibiting promise in treating and protecting against sepsis-induced cardiomyopathy [133]. The gene discussed is DNM1L; the disease is cardiomyopathy.