DUOX2 and cyclic hematopoiesis: However, 7 patients were excluded from the study: 5 patients (THD-2, THD-19, THD-20, THD-21, and THD-31) with likely benign variants in the DUOX2 gene that could not explain their phenotype; patient THD-4 with likely pathogenic variants in TG that were considered the cause of their CH; and patient THD-15 because of the lack of clinical data due to loss to follow-up.