Our data revealed that the acquisition of TIGIT observed on NK cells from CRC pts and upon coculture with CD15+ monocytes is accompanied by a concomitant downregulation of DNAM-1 expression (Figure 5A) and other activating receptors, such as NKp46, NKp30 and NKG2D (Figure S1 and Figure 4C), thus suggesting an impairment in tumor cell recognition and killing. This evidence concerns the gene TIGIT and colorectal carcinoma.