TIGIT and neoplasm: Our data revealed that the acquisition of TIGIT observed on NK cells from CRC pts and upon coculture with CD15+ monocytes is accompanied by a concomitant downregulation of DNAM-1 expression (Figure 5A) and other activating receptors, such as NKp46, NKp30 and NKG2D (Figure S1 and Figure 4C), thus suggesting an impairment in tumor cell recognition and killing.