CSF2 and neoplasm: Although M-MDSCs and G-MDSCs differentiate as monocytes and neutrophils, respectively, increased production of tumor-released factors, such as GM-CSF, CSF-1 and other growth factors, can result in abnormal myelopoiesis responsible for the accumulation of a defined population of monocyte-like precursors of granulocytes (MLPGs) [17].