The induction of IFNs remained weak at 4 h p.i. in A and B PDLs; however, strong induction was observed in C PDL, which displayed the highest level of viral expression, as shown in Figure 2D. These results suggested that the IFN response was related to the level of viral infection in PDL fragments and that viral spread in the PDL was able to promote a rapid and marked inflammatory response. The gene discussed is IFNA1; the disease is viral infectious disease.