Since α-lipoic acid moderately inhibits HDACs (see Table 1) and HDAC inhibition in cancer cells has been linked to changes in gene expression, we investigated the protein expression of apoptosis- and cell survival-related proteins upon 48 h treatment with the physiological R-enantiomer of α-lipoic acid, exemestane, and their combination in MCF-7 and T47D cells. This evidence concerns the gene HDAC9 and cancer.