In addition, the main ligand of EGFR, epidermal growth factor (EGF), was evaluated in canine mammary carcinoma cell lines to play a role in the proliferation, migration, angiogenesis, and survival [13], suggesting that the EGFR pathway may be involved in the stimulation of angiogenesis as observed by Carvalho et al. [14] in which expression of EGFR was correlated with microvessel density. This evidence concerns the gene EGF and breast carcinoma.