One previous study associated the expression of c-KIT, VEGFR-2, and PDGFR-β and TOC antitumor response in vitro [31] and several studies have investigated TOC antitumor response in vivo, without association with c-KIT, VEGFR-2, and PDGFR-β tumor expression [32,33,34]. This evidence concerns the gene PDGFRB and neoplasm.