ERBB2 and cancer: In humans, overexpression of surface receptors such as epidermal growth factor receptors 1 and 2 (EGFR and ERBB2/HER2) was associated with the development and progression of certain types of cancer, including breast cancer (BC), head and neck cancer (HNSCC), stomach, pulmonary adenocarcinoma, and bladder cancer [2,3,4,5,6,7].