TNFSF11 and periapical periodontitis: The objective of this study was to explore the impact of an IRAK-4 inhibitor on the RANK/RANKL pathways in the macrophages THP-1 and peripheral blood mononuclear cells (PBMC) obtained from patients with apical periodontitis when exposed to Enterococcus faecalis and its major virulence factor, the lipoteichoic acid (LTA).