The reduction in PCNA expression correlates with the reduction in tumor volume, suggesting that treatment with AgNPs-G has a direct effect on the divisional capacity of tumor cells, which has also been described in studies using a small molecule (PCNA-I1S) that can directly bind to PCNA, stabilize the trimer structure, and reduce chromatin-associated PCNA, thereby selectively inhibiting tumor cell growth and inducing apoptosis [22]. The gene discussed is PCNA; the disease is neoplasm.