CCL2 and pulmonary arterial hypertension: Additionally, 15-Lipoxygenase (15-LO)/15-hydroxyeicosatetraenoic acid (15-HETE) signaling can promote coagulation and platelet activation in the pulmonary vascular thrombotic lesions of PAH models, which was suppressed and reversed by MCP-1 inhibition in hypoxia-induced rats [103].