GPx1 is closely related to tumorigenesis, mainly due to its role in eliminating hydroperoxides; it is highly expressed in most cancers and has higher expression in tumor tissues, including skin melanoma, testicular germ-cell tumors, glioblastoma multiforme, pancreatic adenocarcinoma, thyroid cancer, renal papillary cell carcinoma, acute myeloid leukemia, endometrial cancer, low-grade glioma, and ovarian serous cystadenocarcinoma [105]. This evidence concerns the gene GPX1 and cancer.