In a mouse model of viral diseases, we showed that a small-molecule inhibitor of MyD88, compound 4210, limited the sequestration of IRF3/IRF7, resulting in increased IRF phosphorylation and type I IFN response; suppressed viral replication; and improved survival, weight change, and clinical disease scores [25] (see Figure 2). The gene discussed is MYD88; the disease is viral load.