In fact, some of the other maladies associated with α-synuclein misbehavior include neurodegeneration with brain iron accumulation type 1 (NBIA1), pure autonomic failure, Down’s syndrome, amyotrophic lateral sclerosis-parkinsonism-dementia complex of Guam (Guam ALS/PDC), multiple system atrophy (MSA), and several LB disorders (that, in fact, might represent a clinical continuum [24]), such as sporadic and familial PD, dementia with Lewy bodies (DLB), diffuse Lewy body disease (DLBD), the Lewy body variant of Alzheimer’s disease (LBVAD), and PD dementia (PDD) [25,26,27,28,29,30,31,32,33]. This evidence concerns the gene SNCG and Down syndrome.