In THP-1 monocytic cells, AQP3 is implicated in IL-6, pro-IL-1β, and TNFα transcription via TLR4 engagement upon LPS priming [79], and the activation of the NLRP3 inflammasome, known to be upregulated in sepsis [80], is influenced by AQP3 expression [79]. Here, AQP3 is linked to Sepsis.