The experiment also showed that overexpression of COX-2 and PGE2 can significantly activate the JAK-2/STAT-3 pathways, and thus, the ability of BRB to block the entire cascade COX-2/PGE2/JAK-2/STAT3 makes it an extremely promising option in CRC therapy [68]. The gene discussed is STAT3; the disease is colorectal carcinoma.