PTEN and colorectal carcinoma: Another study showed that in vitro treatment of BRB with cell CRC lines HT-29, SW-480, and HCT-116 (IC50 was 34.6, 44.3, and 32.1 μM, respectively) led to a decrease in the expression of aquaporins 1, 3, and 5 in CRC cells and also increased the expression of the PTEN gene (phosphatase and tensin homolog deleted on chromosome 10).