Researchers have also reported the existence of another potentially significant BRB–CRC cell molecular interaction: inhibition of the pro-inflammatory TLR4/NF-κB/p65/IL-6/STAT3 signaling pathway with simultaneous intensification of expression of proteins conditioning the connection of epithelial cells in the tissue area: occludin and ZO1 protein [75]. Here, STAT3 is linked to colorectal carcinoma.