F8 and Von Willebrand disease: Other possible causes include mutations in other genes causing an HA-like phenotype, such as mutations in von Willebrand factor affecting the FVIII binding site in von Willebrand disease (VWD) type 2 Normandy (2N) [34,35], or mutations in the LMAN1 gene (lectin, mannose-binding 1) [36,37] or MCFD2 gene (multiple coagulation factor deficiency 2 protein) [38], leading to combined deficiencies of factor V and FVIII.