For instance, in acute myeloid leukemia (AML) cell lines, the absence of the RNA m6A writer WTAP can inhibit proliferation and promote differentiation and apoptosis [14]; the deletion of the methyltransferase catalytic subunit METTL3 suppresses translation of its target genes (MYC, BCL2, and PTEN), thereby promoting differentiation and apoptosis of cancer cells [15]; METTL14 increases m6A methylation of MYB and MYC, inhibits the differentiation of AML cells, and promotes cell proliferation, leading to tumorigenesis [16]. This evidence concerns the gene BCL2 and acute myeloid leukemia.