ASH1L and facioscapulohumeral muscular dystrophy: Cabianca et al. demonstrated that in facioscapulohumeral muscular dystrophy, the elevated expression of DBE-T (a lncRNA) induces FSHD by recruiting Ash1L (a trithorax group protein) to the FSHD locus, driving histone H3 lysine 36 dimethylation, chromatin remodeling, and 4q35 gene transcription [197].