A significant increase in BACE1 activity was shown in AD patients compared to CTRL and FTD patients (mean ± SEM; AD, 20.88 ± 3.41 kU/L vs. CTRL, 10.97 ± 0.73 kU/L, Generalized Linear Model, padj < 0.001; AD vs. FTD, 12.96 ± 0.92 kU/L, Generalized Linear Model, padj = 0.007). The gene discussed is BACE1; the disease is Alzheimer disease.