Fibroblast growth factor 19 (FGF19) is strongly associated with CRC liver metastasis (CRLM) via activation of FGFR4/JAK2/STAT3 signaling-mediated hepatic stellate cells polarization to inflammatory CAFs, which further promote neutrophil infiltration and NETs formation for liver colonization of CRC cells; inhibition of neutrophil by neutralizing antibody blocks FGF19-mediated CRLM [167]. This evidence concerns the gene JAK2 and colorectal carcinoma.