Unique CAMs-M2 interact with CRC cells via integrin-associated protein (IAP)/SIRPα signaling, promoting cancer cell growth and migration through the release of IL-4, IL-8, IL-10, and cysteinyl leukotriene D4 (LTD4), and increased IL-10 levels further enhance the function of CAMs-M2 [150,151]. The gene discussed is CD47; the disease is cancer.