High MAGL levels are significantly associated with poor differentiation and a shorter survival time in hepatocellular carcinoma (HCC); MAGL knockdown inhibits apoptosis, proliferation, and invasion via the downregulation of lysophospholipids (PGE2 and LPA), indicating that secondary lipid metabolites (PGE2/LPA) regulated by MAGL are essential for tumor aggressiveness. This evidence concerns the gene MGLL and hepatocellular carcinoma.