Elevated CD66b+CD16+ neutrophils (N2) and reduction of NK cells are observed in CRC tumor samples; the co-culture of CRC cells and immune cells indicates that neutrophils inhibit the anti-tumor activity of the NK cells and promote tumor growth by disturbing lipid raft formation-mediated by CD16/TAK1/NF-γB pathway; CD16 knockdown restores the immunosuppression in CRC patient-derived organoids [162]. This evidence concerns the gene CEACAM8 and colorectal carcinoma.