HIF1A and hepatocellular carcinoma: Hypoxia plays a role in the regulation of lipid metabolism by upregulating lipogenesis-related genes (LPIN1, FASN, and SCD1) and FA transport protein (FABP1), and downregulating FAO-related genes, medium- and long-chain acyl CoA dehydrogenases (MCAD and LCAD); hypoxia promote cancer progression by inhibition of HIF-1-FAO/LCAD-PTEN axis; decreased LCAD is significantly correlated with late-stage HCC [103].