Compared to the control, silencing IL-6 shows smaller tumor weight, reduced UPC1 expression in scWAT, and rescued CAC phenotype in colon cancer model; blocking IL-6 by anti-IL-6 antibody results in a reduction of body fat and UPC protein level in scWAT of melanoma mice model [63]. The gene discussed is IL6; the disease is malignant colon neoplasm.