PDK1 and colorectal carcinoma: FABP5 promotes CRC tumor organoid growth via upregulation of hypoxia-inducible factor 1 (HIF-1); knockdown of FABP5 reverses the growth effects by downregulates the HIF-1α protein level and its downstream target genes, such as vascular endothelial growth factor (VEGF), carbonic anhydrase (CA9), pyruvate dehydrogenase kinase 1 (PDK1), BCL2 interacting protein 3 like (BNIP3L), and lysyl oxidase (LOX) [94].