The results of the enrichment analysis revealed that the top ten significant KEGG pathways associated with the DEOSGs included MAPK, ErbB, GnRH, TNF, FoxO, the Fc epsilon RI signaling pathway, Kaposi sarcoma-associated herpesvirus infection, proteoglycans in cancer, bladder cancer, and glioma (Figure 3A). The gene discussed is TNF; the disease is central nervous system cancer.