NOS3 and hypertensive disorder: This reduction in blood pressure may be linked to the presence of valuable compounds in YBE such as ursolic and chlorogenic acid, isoquercetin, cymaroside, etc. Previous research highlighted the effects of ursolic acid in hypertension management through a decrease in the level of endothelin-1 (endothelium contracting factor) and elevated activity of endothelial nitric oxide synthase (eNOS) [6,23].