P2RX7 and rheumatoid arthritis: For instance, in rheumatoid arthritis (RA), a common autoimmune disease causing cartilage damage [110], the acid-sensitive channels [111], transient receptor potential channels [112], P2X7 receptors [113], and Piezo channels [114], among others, have been involved in RA pathogenesis by the regulation of calcium ion-related signaling pathways, which results in synovial hyperplasia, structural damage, and inflammatory burst [110].