IL10 and rheumatoid arthritis: A study by Hee et al. (2007) investigating the role of the IL-10 gene promoter polymorphism in RA in Malaysian patients showed that the haplotype comprising all minor alleles in rs1800896, rs1800871, and rs1800872 (ATA haplotype) was associated with lower IL-10 production when compared with the other haplotypes, and the RA patients who did not display the ATA haplotype produced significantly higher levels of IL-10 when compared with those carrying either one or two polymorphisms [48].