FBN1 and Marfan syndrome: Studies on nonsyndromic sporadic TAAD (nssTAAD) have shown the presence of rare pathogenic variants and common single-nucleotide polymorphisms (SNPs) in genes associated with Marfan syndrome (FBN1) and Loeys–Dietz syndrome (TGFBR1 or TGFBR2) as well as rare copy number variants (CNVs) affecting MYH11, ELN, or TGFB2, whose mutations correlate with familial types of TAAD [1,5,6,7,8].