In patients with sporadic thoracic aortic dissection, rare pathogenic variants and CNVs have been identified in hereditary-aneurysm genes, including FBN1, MYH11, EFEMP2, TGFBR2, FBN2, COL3A1, and MYLK, and 28% of the patients have >1 variant of unknown significance (VUS) in the genes of hereditary aneurysms; this occurrence is significantly higher than in a control group [9,10,11]. The gene discussed is COL3A1; the disease is aneurysm.