ACTN3 and chronic obstructive pulmonary disease: Although genetics in sport has been deeply studied, only six single nucleotide polymorphisms (SNPs) have been implicated in these factors, such as I/D (rs4646994) in angiotensin-converting enzyme (ACE) involved in hypertension, causing, among others, cardiovascular cerebrovascular diseases [25], chronic obstructive pulmonary disease (COPD) [26,27] and idiopathic pulmonary fibrosis [28], alpha-actinin 3 (ACTN3) c.1729C>T (rs1815739), involved in cardiometabolic fitness [29], muscle fiber composition, strength, and risk of muscle injury [30,31].