There might be other important genetic factors not considered, like Insulin-like growth factor I (IGF-1), interleukins 6 and 15 (IL6, IL16), nitric oxide synthase 3 (NOS3), peroxisome proliferator-activated receptor alpha (PPARA) and vitamin D receptor (VDR) implied in inflammation, muscle disorders, and peripheral vasodilatation during physical activity [21]. Here, NOS3 is linked to muscular disease.