CXCL12 and acute lymphoblastic leukemia: Although JM#170 blocked the CXCL12-induced calcium flux in both SupB15 and 697 cell lines (human BCR–ABL1− ALL cell line, Figure 6A–D), the killing effect was only observed in BCR–ABL1+ SupB15 cells (Figure 6E, Supplementary Figure S5).