In neonatal rat cardiac myocytes: ↑ miR-451 expression in a dose- and time-dependent mannerIn cardiomyocyte-specific miR-451 knockout mice: cardiac hypertrophy and contractile reserves were ameliorated, ↑ Cab39 and phosphorylated AMPK, and↓ mTOR. Here, MTOR is linked to cardiac hypertrophy.