NFKB1 and Autoimmunity: This enzyme plays an important role in the regulation and induction of the immune system, including the negative regulation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), ubiquitin editing, controlling immune cell differentiation, regulation of inflammatory cytokines, protection against autoimmunity, and the regulation of NLRP3 inflammasome formation.