Numerous studies have documented disruptions in bioenergetic pathways across severe mental illnesses such as altered glycolytic enzyme activity [6,39,40,41,42,43,44,45], TCA cycle and ETC enzyme levels [6,7,46,47,48], astrocyte–neuron coupling and lactate metabolism [5,49,50,51], and pentose phosphate pathway and antioxidant metabolism [5,49,52,53]. The gene discussed is HK1; the disease is psychiatric disorder.