In mice with ovalbumin-induced asthma, significantly increased p-GSK3β-Ser9 levels were associated with reduced lung function and pulmonary inflammation, i.e., increased numbers of leukocytes and levels of TNF, IL-2, -4, -5, -13, -33, and IFN-γ in BALF, enhanced serum IgE, inflammatory cell invasion and NF-κB-p65 phosphorylation in lung tissue. The gene discussed is IGHE; the disease is asthma.