GSK3B and Parkinson disease: Age-related PD-like deficits can also be induced by neuron-specific seipin KO as reflected by impaired motor coordination, α-synuclein fibril formation in dopaminergic neurons and their progressive decline, as well as increased p-GSK3β-Tyr216 and decreased p-GSK3β-Ser9 levels in aging mice [180] (Figure 5).