NOS2 and Cognitive impairment: Beneficial effects include reduced behavioral/cognitive impairment, tau phosphorylation [155,156,157], neuroinflammation (NF-κB levels [155], microglia activation [156,157], COX-2 and inducible NO synthase (iNOS) mRNA/protein levels [156], TNF, IL-1 β, Il-6 mRNA levels [158]), oxidative stress (e.g., GSH levels) [156], as well as neuronal and synaptic loss [158].