In other DSS-dependent UC models, colitis was similarly attenuated under conditions involving GSK3β inactivation, e.g., in GSK3 inhibitor- (LiCl [105,106], SB216763 [106], 6-(methylsulfinyl)hexyl isothiocyanate [107]), P2Y2 receptor agonist- [108], and CO-treated [105] or CD97 transgenic mice [109]. This evidence concerns the gene GSK3B and colitis.