Major indications of airway inflammation in a murine house dust mite-induced asthma model are enhanced inflammatory cells in peribronchial/perivascular areas and BALF, IgE levels in BALF and serum, and cytokine levels (IL-4, -5, -13, and eotaxin-1) in BALF and lung homogenates. This evidence concerns the gene IGHE and asthma.