In a rat model of diethylnitrosamine (DEN)-induced liver fibrosis, reduced body/liver weight, signs of liver inflammation and injury (inflammatory infiltration, steatosis, fibrous septae, collagen accumulation), increased liver enzyme activity (e.g., alkaline phosphatase (ALP), AST, ALT), and hepatic oxidative stress (e.g., increased MDA and lipid oxidation, decreased SOD) were observed. The gene discussed is GPT; the disease is steatosis.