Research highlights the importance of PTENP1 across various cancers, including prostate cancer [7], HCC [8], OSCC [9], and clear cell renal cell carcinoma (ccRCC) [6] in regulating the miR-21/PTEN axis, thereby influencing EMT, drug resistance, and other cellular functions. The gene discussed is PTENP1; the disease is hepatocellular carcinoma.