It has also been investigated for its ability to mitigate liver fibrosis associated with cirrhosis-associated portal hypertension, where it influences factors like Kruppel-like factor-4, endothelial nitric oxide synthase (eNOS), and inflammatory responses [156,157,158,159,160,161,162,163,164,165]. The gene discussed is NOS3; the disease is Hepatic fibrosis.