TBP and Huntington disease: In addition, dysregulated miR-146a-5pa may contribute to HD pathogenesis by targeting TATA-binding protein (TBP) [146] miR-146a-5pa may also be involved in several other pathways possibly common for AD and HD, a potentiality that might explain the amnesia-like and neuropsychiatric manifestations that appear in both of these CNS diseases.