Researchers also noticed that 74.8% of selected study cases expressed Grem1 in cardiomyocytes of progressing HF, ranging from very low to very strong intensity of immunohistochemical Grem1 reaction, further emphasizing a significant Grem1 role in the remodeling of cardiomyocytes advancing towards symptomatic HF. This evidence concerns the gene GREM1 and hydrops fetalis.