SPP1 and hydrops fetalis: Furthermore, Li J. et al. determined that significant dynamic changes of OPN expression and cellular morphometric changes start manifesting quite early after exposure to the injuring factor, with less significant dynamic changes of OPN expression being apparent after 12 weeks of implementing a pressure overload-induced HF experimental model on animals [9], supporting the fact of OPN biological significance at the early stages of cardiomyocyte injury and its effect on cellular geometry changes.