Hepatic qPCR analysis revealed that both female and male OD mice exhibited significantly increased mRNA expression of pro-inflammatory mediators such as tumor necrosis factor (TNF, Figure 2A), interleukin 1α (IL1α, Figure 2B), interleukin 1β (IL1β, Figure 2C), intercellular adhesion molecule 1 (ICAM1, Figure 2D), monocyte chemoattractant protein 1 (MCP1, Figure 2E), and chemokine ligand 5 (CCL5, Figure 2F) in comparison to lean control mice. This evidence concerns the gene ICAM1 and osteochondritis dissecans.