Most of the CRSwNP patients cluster into a subgroup typically dominated by Corynebacterium.Most of the CRSwNP patients cluster into a subgroup associated with peroxisome proliferator-activated receptor gamma (PPAR-y) and retinoic acid-inducible gene I (RIG-I) signaling pathways and a significant increase in IL-5. The gene discussed is IL5; the disease is chronic rhinosinusitis with nasal polyps.