At the species level, it is notable that Corynebacterium accolens was negatively correlated with eosinophilic cationic protein (ECP) [24] and Eotaxin-3 [84], while CRSwNP patients with S. epidermidis isolated showed an upregulation of trefoil family factor peptide 3 (TFF3), involved in the preservation of epithelial surface integrity, in middle nasal turbinate and NPs [69]. This evidence concerns the gene TFF3 and chronic rhinosinusitis with nasal polyps.