Most of the CRSwNP patients cluster into a subgroup typically dominated by Corynebacterium.Most of the CRSwNP patients cluster into a subgroup associated with peroxisome proliferator-activated receptor gamma (PPAR-y) and retinoic acid-inducible gene I (RIG-I) signaling pathways and a significant increase in IL-5. This evidence concerns the gene PPARG and chronic rhinosinusitis with nasal polyps.