IgE and IL-5 were negatively correlated with Geobacter anodireducens/sulfurreducens and Pelomonas puraquae.IL-5 was negatively correlated with Corynebacterium macginleyi and eosinophil cationic protein (ECP) with Corynebacterium accolens, Corynebacterium macginleyi, and S. pneumoniae.ECP and IL-5 were positively correlated with E. coli (CRSwNP+AS patients).Specific IgE to staphylococcal enterotoxins (SE-IgE) was significantly more frequent in CRSwNP with asthma and correlated with disease severity. The gene discussed is RNASE3; the disease is asthma.