CRSwNP patients were grouped in subject clusters associated with Staphylococcus, Corynebacterium, Streptococcus, and Propionibacterium.IL-8, cluster of differentiation (CD68)-positive macrophages, eosinophils, neutrophils, plasma cells, and IL-5 were significantly elevated in CRSwNP patients. The gene discussed is CD68; the disease is chronic rhinosinusitis with nasal polyps.