An abundant lipopolysaccharide (LPS) was found in the peripheral blood, especially for NECRSwNP patients.LPS levels were positively correlated with glucocorticoid receptor-beta (GR-β) expression in CRSwNP.Neutrophils and macrophages were the principal inflammatory cells containing LPS. This evidence concerns the gene GZMB and chronic rhinosinusitis with nasal polyps.