Men with severe AS and evidence of concomitant, pre-interventional PH had consecutively and significantly higher IGF-BP2 levels, both before and after TAVR, than in male counterparts without previously established PH (baseline: p = 0.022; 24 h post-TAVR: p = 0.007; 96 h post-TAVR: p = 0.026; 3 months post-TAVR: p = 0.036). The gene discussed is IGFBP2; the disease is aortic valve stenosis.