POMC and obesity due to leptin receptor gene deficiency: During a study on 10 participants with POMC and 11 with LEPR deficiency, 80% in the first group and 45% in the second achieved at least 10% weight loss at approximately 1 year, and reduction in hunger was observed at 27.1% (n = 7; 90% CI −40.6 to −15.0; p = 0.0005) in the POMC trial and 43.7% (n = 7; 90% CI −54.8 to −29.1; p < 0.0001) in the LEPR trial [78].