Besides the role of reduced Serca2 activity in contributing to the HF phenotype of adult TazPM♂ mice, the observed changes in pCaMKII and pPKA expression may also contribute to contractile failure via dysregulation of voltage-gated Ca2+ and Ca2+ release channels on the SR membrane, Pln alteration, or a combination of these [27,28]. This evidence concerns the gene PLN and hydrops fetalis.