CASP1 and bacterial infectious disease: Collaborating with PRRs, inflammasomes instigate host defense pathways, contributing to the elimination of various viral and bacterial infections, including those induced by M. tb. Central to their functionality is the activation of inflammatory caspase 1, a key player in the maturation and release of proinflammatory cytokines, as well as in pyroptosis, which is an inflammatory form of cell death in infected cells that can either be caspase 1- or caspase 11-dependent [7,13].