A Q-Q plot illustrated SNP loci acquired from the GWAS data, revealing significant associations with glaucoma Figure 7A. Furthermore, performing precise site analysis of the GWAS data outlined the critical SNP loci dispersed within regions of genetic richness Figure 7B. Notably, the pathogenic regions aligned to our hub genes were identified; SERPINA3, LCN2, MMP3, S100A9, IL1RN, and HP were situated within the pathogenic region of chromosomes 16, 9, 11, 1, 2, and 16, respectively. Here, SERPINA3 is linked to glaucoma.