MiR-223, along with miR-106a-5p are hub miRNAs for post-transcriptional control of solute carrier family 4 member 4 (SLC4A4), a gene product with pleiotropic oncosuppressive functions whose expression is downregulated in CRC; increased expression of both miRNAs was described in CRC samples [75]. This evidence concerns the gene SLC4A4 and colorectal carcinoma.