HAX1 and cancer: Overexpression of miR-223 downregulates its direct target HCLS1-associated protein X-1 (HAX1) (an anti-apoptotic gene); sensitizes cancer stem cells (CSCs) to TRAIL-induced apoptosis via the mitochondria/ROS pathway; and subsequently activates the effectors caspase-9, caspase-7, and caspase-3 [137].