CML cell lines co-treated with 2-methoxyestradiol (an endogenous estrogen metabolite) and ascorbic acid (an antioxidant) showed increased miR-223 and decreased FLT3 expressions, which consequently induced apoptosis by blocking the PI3K/AKT pathway; the co-treatment also inhibited tumor growth in a mouse model [271]. The gene discussed is FLT3; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.