During targeted sequencing of genes relevant for CLL, Rodríguez-Vicente and colleagues identified a common polymorphism (rs2307842) within the 3′UTR of the HSP90B gene, encoding heat shock protein 90 alpha family class B member 1 (HSP90AB1), and demonstrated that, in CLL cells, HSP90AB1 is a direct target of miR-223. The gene discussed is HSP90AB1; the disease is B-cell chronic lymphocytic leukemia.