A contribution of keratinocytes would also explain the rather weak differences in calcium fluxes in the DRG cultures of Advillin-LPAR5−/− versus LPAR5-flfl cultures, agreeing with a recent study, in which LPAR5-mediated signaling of keratinocytes was shown to drive the pathogenesis of psoriasis [79]. This evidence concerns the gene AVIL and psoriasis.