Taking into account the development of breast cancer as a function of hormone receptors, in the study carried out by Wang et al. (2022) in 439 women with breast cancer (and 439 controls) of Asian origin, the influence of the MTR rs1805087, MTHFR rs1801133, ALDH1L1 rs2002287 (G > A), DNMT1 rs2228611, and DNMT3B rs2424908 (C > T) variants on breast cancer was examined. The gene discussed is MTHFR; the disease is breast carcinoma.