While the connection between KIF1A mutations and the characteristic extranuclear aggregates of TDP-43 in ALS is not yet understood, other kinesins, such as DCTN1, have been reported to disrupt the dynamics of stress granules and promote the formation of TDP-43 cytoplasmic aggregation in cultured cells [15]. The gene discussed is KIF1A; the disease is amyotrophic lateral sclerosis.