SIX1 and BOR syndrome: The branchio-oto-renal (BOR) and branchio-otic (BO) syndromes represent a complex spectrum of rare, genetically heterogeneous conditions characterized by anomalies affecting the ears, branchial arches, and renal system [1,2] Certain individuals may display symptoms typical of BOR/BO syndrome but lack renal abnormalities, leading to diagnoses of branchio-oto syndrome-1 [3] (BOS1; OMIM#602588) or branchio-oto syndrome-3 [4] (BOS3; OMIM#608389).